Novavax
  • 24-Aug-2017 to 23-Oct-2017 (EST)
  • Bioprocesses R&D
  • Rockville, MD, USA
  • Full Time - Exempt

Are you ready to work for one of Washington's Top Workplaces?  At Novavax, a clinical-stage vaccine company, we are creating tomorrow's vaccines today! We seek to attract, develop, and retain talented people who share our passion for science, medicine, and human health. We foster an environment of teamwork and collaboration, built on a culture that values and appreciates its employees. We are a fast-paced company that provides employees with opportunities to achieve personal and professional goals while also maintaining a balance between work and personal life.

We are seeking a highly motivated Scientist/Sr. Scientist to join our Downstream Process Development Department in Rockville, MD. Qualified individuals will play a leading role on downstream process development and ensure scientifically sound design and scalable purification processes are created. The position is a hands-on position with responsibility for purification process development and characterization.  The candidate should have an in-depth understanding of protein chemistry, biochemistry and separation science technology, especially chromatography and/or cell lysis and product recovery.  The candidate should also be able design robust, scalable, high purity / high yield purification processes and able to readily apply statistical design of experiments (DoE) and concepts of process validation to process development.  The ability to understand and interpret moderately complex data is essential and the position requires strong organizational and documentation skills.

Responsibilities include but are not limited to:

  • Developing robust, high purity / high yield, scalable downstream purification processes for clinical phase membrane or secreted biologic candidates.
  • Independent design and execution of bench-scale experiments to support process development, optimization and characterization.
  • Identifying and resolving complex technical problems in process development.
  • Advising or providing direction to associate level scientists or members of project teams in the planning and execution of laboratory experimentation, as well as resource identification and allocation.
  • Interpreting results, drawing conclusions and presenting data at departmental meetings.
  • Author technical reports, data analysis summaries, SOPs and other technical documentation as needed.
  • Maintaining and monitoring process development equipment, understanding compliance with Good Laboratory Practices and laboratory safety procedures, providing training and support to junior level staff in the laboratory.
  • Collaborating with colleagues from Discovery, Process Development, Analytical Development, Technology Transfer, Manufacturing, and QA/QC teams.
  • Supporting tech transfer, manufacturing and validation as needed.
  • Supporting and troubleshooting operations in the GMP manufacturing facility as needed. Assisting with resolution of manufacturing deviations.
  • This position is expected to be both hands on in the laboratory and acting as a technical lead / support role for associate level scientists.

Minimum requirements:

  • A Ph.D. in Biochemistry or related field with 5 years of experience or M.S. with 10 years of experience in pharmaceutical or biotech industries R&D department.
  • Strong downstream purification experience in an industrial setting, especially for protein based biotechnology products; direct experience with virus-derived membrane or secreted products, and/or viral particles is a plus.
  • Must have extensive hands on experience with KTA Avant/Explorer and good knowledge of various protein purification techniques including ion exchange, affinity, mixed mode and HIC chromatography, as well as normal and tangential flow filtrations.
  • Experience with cell culture harvest and separation technologies such as cell lysis, flocculation, centrifugation, and depth filtration.
  • Knowledge and experience with statistical design of experiments (DoE) and JMP software is a plus.
  • Should be capable of performing multiple functions in a fast paced environment. Strong technical protocol/report writing and good organization skills are required.
  • Knowledge of regulatory guidelines and cGMP requirements is required.
  • Excellent record keeping abilities to adequately record, analyze and document data to meet regulatory requirements.
  • Demonstrated verbal and written skills in communicating and reporting technical information.

Novavax, Inc. (Nasdaq: NVAX) is a clinical-stage biopharmaceutical company creating novel vaccines to address a broad range of infectious diseases worldwide. Using innovative virus-like particle (VLP) and recombinant nanoparticle technology, as well as new and efficient manufacturing approaches, the company produces potent vaccine candidates to combat diseases, with the goal of allowing countries to better prepare for and more effectively respond to rapidly spreading infections. Novavax is committed to using its technology platforms to create geographic-specific vaccine solutions and is therefore involved in several international partnerships, including collaborations with Cadila Pharmaceuticals of India and LG Life Sciences of Korea. Together, these companies have worldwide commercialization capacity and the global reach to create real and lasting change in the biopharmaceutical field.

Novavax, Inc. offers a base salary, annual bonus, stock options, professional career development/growth opportunities, and a comprehensive benefits package including medical, dental, vision, Rx, STD, LTD, Life, Optional Life, 401(k) plan.

We are an equal opportunity employer that values diversity at all levels. All individuals, regardless of personal characteristics, are encouraged to apply.

 

Novavax
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